Penicillin-induced epileptogenic foci in the rat cortex

Synchronization of double asymmetrical epileptogenic foci in the cerebral cortex of the rat.

Discharges of two asymmetrical penicillin foci progressively synchronized during 25 min after creation of these foci. Section of the corpus callosum seriously impaired but did not completely block this synchronization. Thalamic spreading depression did not significantly change the synchronization in rats with intact corpus callosum. Noncallosal component of synchronization is probably realized ...

Quality of life in childhood epilepsy with lateralized epileptogenic foci

BACKGROUND Measuring quality of life (QOL) helps to delineate mechanisms underlying the interaction of disease and psychosocial factors. In adults, epileptic foci in the left temporal lobe led to lower QOL and higher depression and anxiety as compared to the right-sided foci. No study addressed the development of QOL disturbances depending on the lateralization of epileptogenic focus. The objec...

donepezile prevents morphine-induced apoptosis in rat cerebral cortex

Using network dynamic fMRI for detection of epileptogenic foci

BACKGROUND Epilepsy is one of the most prevalent neurological disorders. It remains medically intractable for about one-third of patients with focal epilepsy, for whom precise localization of the epileptogenic zone responsible for seizure initiation may be critical for successful surgery. Existing fMRI literature points to widespread network disturbances in functional connectivity. Per previous...

Elicitation of cyclic AMP accumulation by norepinephrine in the iron-induced epileptogenic cerebral cortex of rats.

A microinjection of ferric chloride solution into the left frontal cortex of rats induced epileptic discharges which were recorded by electrocorticography. In animals having such electrographic seizure activity 30 to 60 days after the injection, the accumulation of cyclic AMP elicited by norepinephrine was examined in slices from four cortical regions. The accumulation was significantly greater...